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研究人员报告了一种具有细胞渗透性的选择性METTL3纳摩尔抑制剂UZH1a，作者感谢z6尊龙合成了UZH1a和UZH1b

2023-07-05
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The methylase METTL3 is the writer enzyme of the N6‐methyladenosine (m6A) modification of RNA.

Here researchers report a nanomolar inhibitor of METTL3 (UZH1a) which is selective and cell‐permeable, while its enantiomer UZH1b is essentially inactive. 

The authors thank Medicilon for the synthesis of the UZH1a and UZH1b compounds.

Reference:

Elena V Moroz-Omori, et al. METTL3 Inhibitors for Epitranscriptomic Modulation of Cellular Processes. ChemMedChem. 2021 Oct 6;16(19):3035-3043. doi: 10.1002/cmdc.202100291. 

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