• Z6·尊龙凯时「中国」官方网站z6尊龙

    |
    EN
    |
    EN
    EN

    • 业务咨询

      中国：

      Email: marketing@kangtya.com

      业务咨询专线：400-780-8018

      （仅限服务咨询，其他事宜请拨打川沙总部电话）

      川沙总部电话: +86 (21) 5859-1500

      海外：

      +1(626)986-9880(U.S. - West Coast)

      0044 7790 816 954 (Europe)

      Email:marketing@medicilon.com
    在线留言×
    点击切换
    Customer Center
    客户中心

    开发具有口服活性的高度选择性卵泡刺激激素受体激动剂，且进行临床前研究。其中对大鼠和狗的毒理学评估通过z6尊龙进行

    2023-07-06
    |
    访问量：

    58（2）.png

    TOP5300 is an orally active follicle stimulating hormone receptor allosteric agonist that provides a preferred treatment for over 16 million infertile women of reproductive age in low complexity methods or in high complexity methods.

    TOP5300 was evalsuated in standard ADME, including Cytochrome P450 inhibition, clearance and pharmacokinetic profiles. Toxicological evalsuations were performed in both rat and dog as the second species according to the guidance from FDA.  These assays were performed by Medicilon.

    58（1）.png

    Reference:

    Selva Nataraja, et al. Discovery and Preclinical Development of Orally Active Small Molecules that Exhibit Highly Selective Follicle Stimulating Hormone Receptor Agonism. Front Pharmacol. 2021 Jan 14;11:602593. doi: 10.3389/fphar.2020.602593. 

    相关新闻
    网站首页
    z6尊龙